our research
Publications:
- Patel, R.D., Murray, I.A., Flaveny, C.A., Kusnadi, A., and Perdew, G.H. (2009) Ah receptor represses acute phase response gene expression without binding to its cognate response element. Laboratory Investigation. 89, 695-707.
- Flaveny, C.A., Murray, I.A., Chiaro, C.R. and Perdew, G.H. (2009) Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice. Mol. Pharmacol. 75, 1412-20.
- Chiaro, C.R., Patel, R.D., Perdew, G.H. (2008) 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid [12(R)-HETE], an Arachidonic Acid Derivative, Is an Activator of the Aryl Hydrocarbon Receptor. Molecular Pharm. 17(6), 1649-1656.
- Chiaro, C.R., Morales, J.L., Prabhu, K.S., Perdew, G.H. (2008) Leukotriene A Metabolites Are Endogenous Ligands for the Ah Receptor. Biochem. 47(32), 8445-8455.
- Flaveny, C., Reen, R.K., Kusnadi, A., Perdew, G.H. (2008) The mouse and human Ah receptor differ in recognition of LXXLL motifs. Archives of Biochem and Biophysics 471:215-223.
- Morales, J.L., Krzeminski, J., Amin, S. and Perdew, G.H. (2008) Characterization of the Antiallergic Drugs 3-[2-(2-Phenylethyl benzoimidazole-4-yl]-3-hydroxypropanoic Acid and Ethyl 3-Hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as Full Aryl Hydrocarbon Receptor Agonists. Chem. Res. Toxicol. 21, 472-482.
- Murray, I.A., and Perdew, G.H. (2008) Omeprazole stimulates the induction of human insulin-like growth factor binding protein-1 mediated by Ah receptor activation. Pharmacol. Exp. Therapeutics 324, 1102-10.
- Hollingshead, B.D., Beischlag, T.V., DiNatale, B.C., Ramadoss, P., and Perdew, G.H. (2008) Inflammatory signaling Ah receptor mediate syntergistic induction of IL-6 in MCF-7 cells. Cancer Res. 68(10) 3609-3617.
- Beischlag, T.V., Morales, J.L., Hollingshead, B.D., and Perdew, G.H. (2008) The aryl hydrocarbon receptor complex and the control of gene expression. Critical Reviews in Eukaryotic Gene Expression. 18(3):207-250.
- Chiaro, C.C., Patel, R.D., Marcus, C.B., and Perdew, G.H. (2007) Evidence for an Ah receptor-mediated cytochrome P450 auto-regulatory pathway. Mol. Pharmacol. Epub. Mol. Pharm. 72(5) 1369-1379.
- Patel, R.D., Hollingshead, B.D., Omiecinski, C., and Perdew, G.H. (2007) Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor (CAR) levels in murine and human liver. Hepatology, 46, 209-218.
- Morales, J.L., and Perdew, G.H. (2007) CHIP can remodel mature AhR complexes and mediate ubiquitination of both AhR and the hsp90 in vitro. Biochemistry. 46, 610-621.
- Hollingshead, B.D., Patel, R.D., and Perdew, G.H. (2006) Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-hsp90 complexes. Mol. Pharmacol. 70, 2096-2107.
- Patel, R.D., Kim, D.J., Peters, J.M., and Perdew, G.H. (2006) The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicological Sciences 89, 75-82.
- Murray, I.A., Reen, R.K., Leathery, N., Ramadoss, P., Bonati, L., Gonzalez, F.J., Peters, J.M., and Perdew G.H. (2005) Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Arch. Biochem. Biophys. 442, 59-71.
- Ramadoss, P., and Perdew, G.H. (2005) The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleo-cytoplasmic shuttling properties. Biochemistry 44, 11148-59.
- Beischlag, T.V. and Perdew, G.H. (2005) ER-AhR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin inducible gene transcription. J. Biol. Chem. 280, 21607-21611.
- Ramadoss, P., Marcus, C., and Perdew, G.H. (2005) Role of the Ah receptor in drug metabolism. Expert Opin. Drug Metab. Toxicol. 1, 9-21.